赵丹丹,女,医学博士,副教授,2018年硕博连读毕业于哈尔滨医科大学药理学专业,2021年苏州大学心血管病研究所博士后出站后留任副研究员,硕士生导师。2023年进入15vip太阳集团工作。研究方向为多潜能干细胞的心肌细胞分化、心脏类器官构建以及非编码RNA与心血管疾病分子机制。近年来,主持国家自然科学基金青年项目1项,中国博士后面上项目1项,以共同第一作者身份在相关领域发表SCI研究论文6篇。
联系方式:E-mail: dandan0103@126.com
研究方向
(1)非编码RNA参与调控心脏疾病。
(2)诱导多潜能干细胞与心脏类器官。
科研项目
(1)国家自然科学基金青年项目,82000263,CircRNA ALPK2调控多潜能干细胞向心肌细胞分化的作用及机制,2021.01-2023.12,24万元,在研,主持。
(2)中国博士后科学基金面上项目,2018M642316,长链非编码RNA-UCA1调控分选连接蛋白17抑制心肌梗死,2019.01-2021.06,5万元,结题,主持。
代表性论文
(1) Zhao, Dandan; Li, Xuelian; Liang, Haihai; Zheng, Nan; Pan, Zhenwei; Zhou, Yuhong; Liu, Xiao; Qian, Ming; Xu, Bozhi; Zhang, Ying; Feng, Ying; Qili, Muge; Wu, Qiuxia; Yang, Baofeng; Shan, Hongli ; SNX17 produces anti-arrhythmic effects by preserving functional SERCA2a protein in myocardial infarction, International Journal of Cardiology, 2018, 272: 298-305.
(2) Zhao Dandan; Li Cui; Yan He; Li Tianyu; Qian Ming; Zheng Nan; Jiang Hua; Liu Li; XuBozhi; Wu Qiuxia; Li Xuelian; Liang Haihai; Shan Hongli ; Cardiomyocyte Derived miR-328 Promotes Cardiac Fibrosis by Paracrinely Regulating Adjacent Fibroblasts, Cellular Physiology and Biochemistry, 2018, 46(4): 1555-1565.
(3) Miao, Shumei; Zhao, Dandan; Wang, Xiaoxiao; Ni, Xuan; Fang, Xing; Yu, Miao; Ye, Lingqun; Yang, Jingsi; Wu, Hongchun; Han, Xinglong; Qu, Lina; Li, Lei; Lan, Feng; Shen, Zhenya; Lei, Wei; Zhao, Zhen-Ao; Hu, Shijun ; Retinoic acid promotes metabolic maturation of human Embryonic Stem Cell-derived Cardiomyocytes, Theranostics, 2020, 10(21): 9686-9701.
(4) Yang, Jingsi; Ding, Nan; Zhao, Dandan; Yu, Yunsheng; Shao, Chunlai; Ni, Xuan; Zhao, ZhenAo; Li, Zhen; Chen, Jianquan; Ying, Zheng; Yu, Miao; Lei, Wei; Hu, Shijun ; Intermittent Starvation Promotes Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes, Frontiers in Cell and Developmental Biology, 2021, 9: 687769.
(5) Zhao, Dandan; Lei, Wei; Hu, Shijun ; Cardiac organoid - a promising perspective of preclinical model, Stem cell research & therapy, 2021, 12(1): 272.